AMIPAREN^®

AMIPAREN is a steril injection solution of total amino acids intended For use in hyperalimentation and general parenteral nutrition. AMIPAREN contains relatively larger amounts of branched chain amino Acids (leucine, isoleucine and valine), which suppress protein breakdown and promote protein synthesis in the muscle. A series of preclinical and clinical Studies established that AMIPAREN was effective in sparing protein in various types of insults and malnutrition state.

Composition per 1000 ml :
Total free amino acids : 100 g
Essential amino acids (E) : 59.10 g
Non-essential amino acids (N) : 40.90 g
E / N ratio : 1.44

Branched chain amino acids : 30% w/w %
Total nitrogen : 15.7 g
Na⁺ : 2 mEq
Acetate^- : 120 mEq

Indications :

AMIPAREN is indicated for amino acids supply in the following instances : Hypoproteinemia, malnutrition and pre and or postoperative condition.

Dosage and administration :
Central vein infusion :

The usual adult dosage is 400-800 ml per day by drip infusion via the central vein. The dosage may be increased or decreased depending on the patient's age,symptoms and body weight.

1. AMIPAREN promptly improved and maintained nitrogen balance.
2. The solution promoted synthesis of plasma total protein and albumin.
3. The Urinary 3-methylhistidine / creatinine ratio, an indicator of protein catabolism in the muscle under insult, was low after infusion treatment, indicating a very potent inhibitory efect of the solution on muscle protein breakdown.
4. The plasma concentrations of free amino acids including branched chain amino acids showed minor fluctuation during infusion treatment. Amino acid metabolism was judged to be steady during AMIPAREN therapy.

Storage :

Store below 30^oC, protect from light.

Package :

• 500 ml in Soft Bag.