KIDMIN is a 7.2% amino acid injection containing large amounts of branched-chain Amino acids, such as leucine, isoleucine and valine which inhibit the breakdown of Muscle protein and promote muscle protein
synthesis. KIDMIN also contains some nonessential amino acids, except for glycine, the demand for Which is increased in renal insufficiency. The ratio of essential to nonessential amino acids
Of this solution is 2.6 and each 100 ml contains 1 g of nitrogen, it is thus easy to calculate the nitrogen content of a given dose.
Composition :
Each 1000 ml KIDMIN contains :
Total free amino acids : 72.05 g
Essential amino acids (E) : 52.05 g
Non-essential amino acids (N) : 20 g
E / N ratio : 2.6
Branched chain amino acids : 45.8 % (w/w)
Total nitrogen : 10 g
Na+ : 2 mEq
Acetate : 46 mEq
Indications :
KIDMIN is indicated for the provision of amino acids in the following instances in patients with acute of chronic renal failure : hypoproteinemia, malnutrition.
Dosage and administration : Chronic Renal Failure
Peripheral vein infusion : The usual adult dosage is 200 ml per day, infused via a peripheral vein. The usual infusion rate in adults is 100 ml over 60 min (approximately 25 drops per min) and it should be slowly infused in children, the elderly and seriously ill patients. The dosage may be adjusted according to the patient’s condition, body weight and age. When administered during hemodialysis, it should be infused via the vein side injection port of dialysis circuit starting 90-60 min. before the end of hemodialysis therapy. Regarding calories, more than 1500 kcal per day is recommended to be provided for the efficiency of amino acid utilization.
Central vein infusion : The usual adult dosage is 400 ml per day, infused via a central vein by total parenteral nutrition. The dosage may be adjusted according to the patients condition, body weight and age. More than 300 kcal of nonprotein calories should be administered per 1 g of nitrogen (100 ml of this product) for the efficiency of amino acid utilization.
Acute Renal Failure
The usual adult dosage is 600 ml per day, infused via a central vein by total parenteral nutrition.
The dosage may be adjusted according to the patients condition, body weight and age. More than 300 kcal of nonprotein calories should be administered per 1 g of nitrogen (100 ml of this product) for the efficiency of amino acid utilization.